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ACC/AHA guidelines recommend the use of SGLT2 inhibitors and GLP-1 receptor agonists (GLP-1 RAs) for the treatment of type II diabetes

RESULTS Protection from oxidative damage and environmental stress

Vasodilatory actions of Glucagon-Like peptide 1 are preserved in skeletal and cardiac muscle microvasculature but not in conduit artery in obese humans with vascular insulin resistance

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Gastrointestinal side effects, particularly constipation, occur in approximately 20-30% of patients beginning GLP-1 receptor agonist therapy like semaglutide