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Furthermore, a deficiency in Zip7 shifts macrophage activation towards an M2 phenotype, as evidenced by increased expression of the M2 marker CD206 and reduced levels of the M1 marker NOS2, along with lower production of proinflammatory cytokines such as TNF- and IL-6

Anti-PD-1 therapy remain ineffective in a large number of cancer patients likely due to initial lukewarm response or disappearance of durable responses [6870]

The IL-1 receptor and Rho directly associate to drive cell activation in inflammation

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On the other hand, studies focusing on systemic effects or regenerative applications may require higher doses