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Importantly, two randomised controlled trials (NCT06839248, NCT06654219) investigated the effect of 24-hour clear liquid diet compared to standard fasting guidelines on gastric contents assessed by gastric ultrasound

GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help

Psychological Preparedness Weaning down medications can be psychologically challenging

Its use is limited to controlled research and experimental settings

Clinical research has shown a significant reduction-up to 94%-in the risk of progression to type 2 diabetes among adults with pre-diabetes who used the active ingredient in Zepbound

But its therapeutic benefits differ