it does not mean senolytics cause cancer, but it highlights that the biology of senescence is not uniformly harmful and that senolytic intervention requires careful therapeutic window definition
Thyroid disease and the heart
The Lancet (2021) This Phase 2 dose-finding trial randomized adults with overweight or obesity without diabetes to cagrilintide at doses from 0.3 to 4.5 mg weekly, placebo, or liraglutide 3.0 mg daily as an active comparator across 57 sites in 10 countries
Rectal sensorimotor dysfunction in constipation
As a result, the combined treatment demonstrates a markedly improved antagonistic effect against I/R-induced oxidative stress ( Furthermore, co-administration of AS-IV with these ginsenosides reduces neuronal apoptosis in injured brain tissue by downregulating caspase-3 protein expression in the CA1 hippocampal region of model rats
doi.org/10.1111/j.1467-2494.2005.00261.x Pickart, L., Vasquez-Soltero, J., Margolina, A