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Indeed, a very impressive number of randomized controlled clinical trials (RCTs) and systematic reviews provided robust evidence on the effectiveness of GLP-1RA in PCOS as a new, appealing approach, producing both satisfactory and permanent weight loss, and improvement of insulin resistance at the same time

Adopting a frequent-small-meal dietary pattern slows excessive rapid weight loss, guards against malnutrition and metabolic decline,

The scale-up of small-molecule manufacturing is also fundamentally more straightforward than peptide scale-up

Complementary to this, emerging evidence from behavioral science suggests that digital toolssuch as ecological momentary assessment and ecological momentary interventions delivered through apps or wearables, may help sustain behavioral changes and prevent relapse, particularly in the vulnerable post-discontinuation phase [149]

Patients dealing with nausea in the early weeks often add IV hydration therapy to stay ahead of dehydration