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Therapeutic potential of ROS modulators in viral pathogenesis Numerous studies have investigated the therapeutic potential of inhibiting viral replication and pathogenesis by ROS inhibitors in vitro and in vivo in animal models 55,137

Mackin ST, Nelson SM, Kerssens JJ, Wood R, Wild S, Colhoun HM, et al

Such was the case in the 1980s, when gastroenterologist Jean-Pierre Raufman and biochemist John Pisano conducted experiments in which they injected various animal venoms into guinea pig pancreases

In vivo experiments showed that NO the microbubble-capturing hydrogel accelerated the inflammatory process by promoting the polarization of macrophages from M1 subtype to M2 subtype and regulating VEGF to facilitate angiogenesis

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These findings refined the mechanistic understanding of H 2 S oxidation