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however, clinical trials in humans are very limited

Additionally, data indicate that women with previous neural tube defect (NTD) affected pregnancies should increase their folic acid intake to 4 mg/day PO during the period of greatest risk (1 month before and the 3 months after conception)

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The cause is multifactorial: reduced caloric intake, slower gastric emptying, mild dehydration if water intake drops with appetite, and elevated B12 demand during a rapid metabolic shift

However, it is significant to consult a healthcare provider to know how to do the injections