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[6] Because IGF-1 LR3 retains strong IGF-1R affinity, it initiates the same receptor activation cascade the difference lies in bioavailability, not in the fundamental signaling logic

By keeping natural, endogenous HGH pulsing high via MK-677 while simultaneously running a hyper-targeted exogenous burst of IGF-DES on your hardest training days, you create an almost perfect anabolic environment

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