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Figure 2: Novel Incretin Mimetic Assets for T2DM and Obesity in Phase 2/3 of Development Remaining Unmet Needs Remaining Unmet Needs Though the value proposition of on-market GLP-1 and dual-agonists is strong, several key unmet needs still exist for incretin mimetics across diabetes and obesity, namely: (1) improved efficacy, (2) better tolerability, (3) more convenient options / alternative ROAs, and (4) improved access and affordability

Safety and efficacy for this formulation have not been evaluated by the FDA

In a large study in more than 5000 participants with type 2 diabetes, it was shown that poor glycaemic control was associated with anhedonia but not depression or anxiety [119], suggesting that anhedonia may be more important than general depression scores

Peptides, like proteins, are made from amino acids, but they are much shorter chain and less complex

Chronic gastritis and hypochlorhydria in the elderly

Nishida Y, Yamashita E, Miki W