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Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1related coactivator

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Acting as a growth factor, insulin signaling activates the MAP kinase (MAPK) pathway either through insulin receptor phosphorylation of SRC homology 2 domain-containing protein 1 (encoded by the SHC1 gene) which then interacts with growth factor receptor binding protein-2 (GRB2) or via IRS1 activation

Research published in the Journal of Physiology demonstrated that MOTS-c promotes the conversion of white adipose tissue into beige or brown fat through the ERK signaling pathway