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Upon receptor engagement in pituitary somatotroph cells, Hexarelin has been studied for its activation of intracellular calcium signaling and downstream growth hormone release mechanisms, offering researchers a tool for investigating GH secretion pathways independent of GHRH-driven models

The impact was the same regardless of whether the medication was taken for weight loss or to treat diabetes

Source data are provided with this paper

Mitochondria-targeted polyphenol-cysteine nanoparticles regulating AMPK-mediated mitochondrial homeostasis for enhanced bone regeneration

doi: 10.1038/nature12331 70 ZhangQPanYYanRZengBWangHZhangXet al