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[10] [4] Patients should contact their GP if they experience persistent or severe side effects, signs of allergic reaction (facial swelling, difficulty breathing, severe rash), or if symptoms of B12 deficiency (such as neurological symptoms, severe fatigue, or glossitis) do not improve after several weeks of supplementation

We refer readers to the CY 2022 OPPS/ASC final rule with comment period (86 FR 63529) for further discussion regarding this policy

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The synergy isn't additiveit's multiplicative, provided dosing timing prevents competitive inhibition at the cellular level

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Background and Rationale for Packaging in the OPPS Like other prospective payment systems, the OPPS relies on the concept of averaging to establish a payment rate for services