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Finally, following recent concerns by regulatory agencies regarding a potential increase in suicidal behavior associated with GLP-1RAs 206 , we found 1 recent pharmacovigilance report showing 0.6% suicidal events among 41,236 safety reports for these medications 207 and an emulated target trial of 86,418 older adults with T2DM that did not identify any difference in suicidal ideation or behavior between GLP-1RAs and other antidiabetic medications over 1.5 years 208

doi: 10.1016/0014-5793(95)01006-Z

In practical terms, having a large waist circumference (men 40, women 35) is a major red flag for metabolic and cardiovascular risk

If contaminated, bacteriostatic water can transmit infection or cause an abscess

In a phase I study of advanced resistant solid tumors, GMX-1778 (CHS-828) induced gastrointestinal toxicity and thrombocytopenia

J Gen Virol 85(Pt 11): 31733188