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Current understanding of the liver-brain axis in AD is largely derived from preclinical studies and observational data, leaving causal mechanisms underexplored [296]

At 72 weeks, participants on 15mg lost an average of 22.5% body weight compared to 2.4% in the placebo group

Koliwad said the study's takeaway is that the drugs' known ability to reduce inflammation may be responsible for slowing aging markers, a finding that could broaden who is considered a good candidate for treatment

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[12] What little has appeared since is preclinical and mostly concerns engineered analogues rather than DSIP itself for instance, fusion constructs designed to survive in circulation and cross the blood-brain barrier, tested in chemically-induced insomnia models in mice

Rech, L