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Hence, the drugs are also prescribed to people with obesity

( 4) Pharmacokinetics and Drug Interactions: It acts as a moderate inhibitor of the CYP2D6 enzyme, necessitating caution with concomitant medications that are CYP2D6 substrates

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Another study, the PIONEER 6 trial, found that while semaglutide did not significantly increase the risk of major heart problems, some participants did report palpitations and high blood pressure

Conversely, coffee consumption may suppress appetite in some individuals, potentially complementing semaglutide's appetite-reducing effects

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