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KYN levels were elevated (~ 2.1-fold), and TDO expression (both glial density and intensity in grey and white matter) was significantly higher, suggesting that enhanced KP metabolism may contribute to psychotic features in bipolar disorder

This sensation aligns with what we would expect from nitric oxide-mediated vasodilation

There was a significant between-study heterogeneity ( I 2 = 539 %, P = 0034) in which the study location and duration of studies were revealed as the sources of heterogeneity following subgroup analysis

For the Gemcitabine treatment condition, cells were seeded on day 1 as described above

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Depending on the cellular signaling context, complex II can be formed from complex I, which activates caspase-8 and pro-apoptotic pathways