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In models of LPS-induced inflammation, including RAW264.7 cells, cow endometrial epithelial cells (bEECs), and a mouse endometritis model, catalpol inhibits the secretion and expression of inflammatory factors by targeting TLR4

Researchers investigate BPC-157 for its mechanisms involving nitric oxide pathway modulation, VEGFR2-mediated angiogenesis, and growth factor transactivation

These findings are supported by a small double-blinded, placebo-controlled trial in 50 T2D patients, where 6 weeks of treatment with the DPP4-inhibitor, saxagliptin , increased vasodilation capacity and decreased retinal capillary blood flow (Ott et al., 2014)

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