To Raufman's surprise, in 1981 he discovered that when he put one of the peptides onto guinea pig pancreata, it caused a sharp rise in amylase, an enzyme made in the pancreas and salivary glands in the mouth to help the body break down carbohydrates (Raufman, Tensen, Sutliff
So when a patient is looking at their plate, a plate does not look like a pyramid
That discrepancy is the core of the concern
GLP-1 medications influence appetite and glucose regulation, but they do not independently preserve muscle mass
GLP-1 medications delay gastric emptying, meaning stomach contents may remain present longer than expected even after appropriate fasting
It works as a dual GIP and GLP-1 receptor agonist, helping regulate appetite and blood sugar