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These nutraceuticals likely act through multiple pathways as antioxidants reducing cellular stress in clock-regulating tissues, as ligands for clock-modulating receptors, and by influencing sirtuins and other clock-linked metabolic sensors (Sun et al., 2015)

Ferroptosis in diabetes Since iron plays a key role in metabolic disease processes (such as glucose oxidation) and metabolic regulation (such as hypoxia sensing), it is involved in determining key energy metabolic links such as metabolic rate, gluconeogenesis, fuel selection, and insulin action

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To view a copy of this licence, visit About this article Cite this article Li, H., Fang, Y., Wang, D