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Tirzepatide came off the FDAs official drug shortage list in December 2024, and semaglutide followed in February 2025, eliminating the legal pathway that allowed compounding pharmacies to produce copies of the drugs

Supplements like weight-loss gummies may not have the same level of scientific scrutiny, and they might not address underlying health issues in the same way." Furthermore, the website FAQs direct the consumer to lifestyle factors which can "optimise" the effect of the supplement - a healthy, balanced diet, regular exercise, good sleep habits and reduced stress levels

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Those drugs have different molecular structures than orforglipron, Wharton says, which could explain why orforglipron didnt cause the same trouble