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This is true, for example, of barbiturates and benzodiazepinesthe difference between therapeutic and overdose range can be quite narrow

Moreover, the overexpression of COX-2 is often closely associated with chemotherapy resistance and immune escape processes in tumors, suggesting that COX-2 is an attractive therapeutic target in tumors (107)

A dose escalation trial in 24 adults found that single oral dosages up to 12 g were safe, and adverse effects, including diarrhea, headache, rash, yellow stool, were not related to dose (7)

To reduce non-specific binding, sections were blocked for 2 h at room temperature in a solution containing 5% bovine serum albumin (BSA) and 1% fish gelatin in TBS

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