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Oral bioavailability is estimated at approximately 38%

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Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)

ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

doi: 10.1016/S0022-3468(98)90438-9

in other words, they follow a cyclical pattern