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Using an intention-to-treat approach, we analyzed the overall rate of musculoskeletal pain encounters and risky analgesic use, as well as cardiovascular endpoints following initiation of tirzepatide or phentermine, excluding patients with prior history of the outcomes of interest

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IOW, a HF event requires a patient and clinician to make a decision

The counter argument has been we're going to make more in the United States and that's going to boost the U.S

Your doctor can help you understand if you have any risk factors that might make it more important to avoid combining these medications