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NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinsons disease

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Excluding the inherent limitations that are known to exist with dietary self-reports, we expressed caloric intake relative to body mass, and based on the fact that there were no significant changes over the course of the 8-week study for the dietary variables, and that GSH + CIT did not consume more total calories or protein than the other two groups, dietary intake can likely be ruled out as a possible confounding variable for the increased lean mass

As mentioned earlier, the vast majority of GPX3 is secreted by the renal proximal convoluted tubules, so we speculate that the kidney may be a highly expressed organ of GPX3, and to test our hypothesis, we analyzed the GSE111159 dataset (This dataset mainly detects the gene sequencing of 10 tissues and organs of mouse kidney, liver, brain, lung, thymus, muscle, spleen, stomach, heart and testicle under physiological conditions to understand the gene expression of each tissue and organ) in the GEO database (Gene Expression Omnibus, We found that GPX3 had the highest level of expression in kidney tissue under mouse physiology (Figure 3A), which is consistent with the results of the analysis by Kim et al

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