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Of relevance to this discussion, depressive symptomatology can assume seasonal variation (i.e., seasonal affective disorder), and is associated with non-respiratory sleep disturbances and distinguishable daily motor activity patterns (i.e., comparing depressed individuals with non-depressed individuals and among depressive subtypes)

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant