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Liver IGF-1-deficient mice show a reduction of around 75% in circulating IGF-1 levels and as a consequence due to the lack of negative feedback, these mice have about a fourfold increase in GH production

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A lot of what we call aging results from decreased cellular and organ function

Protein arginine methyltransferase 1 ablation in motor neurons causes mitochondrial dysfunction leading to age-related motor neuron degeneration with muscle loss

Reactive O2 species molecules include peroxide (H2O2) and superoxide anions (O2 with an unpaired electron)