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Appetite suppression (the intended effect) often kicks in even faster, sometimes within hours, making it hard to distinguish between therapeutic response and unwanted side effects

This biological adjustment doesn't mean the drug has failed

As supply stabilizes, the justification for selling chemically identical substances outside the FDA-regulated system becomes harder to defend

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Arq Neuropsiquiatr 1996, 54: 652-654

62,63 Those meta-analyses did not include the FIGHT and LIVE studies, which included patients both with and without diabetes