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Theyre not recommended if you have: Gastroparesis or severe GI conditions A personal or family history of medullary thyroid carcinoma or MEN2 genetic syndrome A history of pancreatitis Pregnancy or are breastfeeding Diabetic retinopathy (risk of worsening with rapid glucose drops) Always share your full health history with your providertransparency is critical for safe recommendations

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Why the Difference Matters The practical implications of these molecular differences: Greater appetite suppression: Semaglutide produces more profound and consistent appetite reduction, leading to greater caloric deficit and weight loss

Data availability No datasets were generated or analyzed during the current study

Among the 60 participants treated with GSBR-1290, only one (2.8%, from the T2DM group) discontinued the study due to drug-related adverse events (AEs)