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The disadvantage is that the longitudinal study is located in a single, small geographic area and may not be nationally representative (although the estimation process attempted to account for the demographics of the entire U.S

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3 = diffuse occurrence of 1116 necrotic cells/HPF (foci of confluent necrosis)

[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care