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Experimental and theoretical ED 50 values were statistically compared using Students t-test

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4a), these data collectively suggest that GLP-1GIPLani enhances body weight loss relative to GLP-1GIP by further accelerating POMC neuronal activity via glutamatergic GLP-1R neurons

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Patients with high GLP-1 receptor responsiveness typically excel on semaglutide alone, while those with variants in GIPR may benefit from tirzepatide or dual-compound therapy for faster results

One ongoing challenge with GLP-1 drugs is manufacturing capacity