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Looking ahead, future work may allow the identification, both at the molecular level and clinical level, of nevi that might be at highest risk of transformation

We discuss how copper also plays a key role in proteostasis and interacts either directly or indirectly with many of the key aggregate-prone proteins implicated in ALS, such as TDP-43, C9ORF72, SOD1 and FUS as well as the effect of their aggregation on copper homeostasis

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Retatrutide is currently undergoing phase 3 trials and we expect it to be available as a prescription medication in 2029

Contribution statement IH, AG-S, and GS-G were responsible for the study concept, design and data acquisition