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References Breunig, E., Michel, K., Zeller, F., Seidl, S., Weyhern, C.W.H.V

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But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

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To confirm the importance of Ser184 phosphorylation of GSTP in the interaction of GSTP with HMGB1, His-tagged GSTP (WT), GSTP-S184D, and GSTP-S184A proteins were expressed in E