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Ann Intern Med (2005) 142(7):54759.10.7326/0003-4819-142-7-200504050-00013 8 SantryHPGillenDLLauderdaleDS

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Suboptimal B12 causes brain fog, difficulty concentrating, mood changes, tingling extremities, and progressive neurological decline

Patients with genetic MTHFR polymorphisms (affecting folate-dependent methionine regeneration) may require indefinite weekly dosing at reduced volume

Insert the needle into the vial at an angle and let the water run slowly down the inside wall of the vial

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