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GLP-1s and SGLT-2 inhibitors for kidney and heart health There is new guidance on incretin-based medications such as Mounjaro (tirzepatide) and Ozempic (semaglutide) and SGLT-2 inhibitors like Jardiance (empagliflozin) and Farxiga (dapagliflozin) for people with type 2 diabetes, emphasizing benefits for the heart and kidneys

doi: 10.1056/NEJMoa1502583 9 ShainAHBastianBC

A meta-analysis of 21 clinical studies showed a weighted mean difference in body weight of 2.9 kg (95% confidence interval [CI] 3.6 to 2.2) with the maximum dose of each one of the GLP-1RAs [43]

Without this, the intervention can become a hypoglycaemia generator rather than a sensitivity improver

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