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To address this limitation, research has concentrated on many strategies, including identifying and developing DPP-IV inhibitors 43,44 , altering the structural makeup of GLP-1, searching for structural analogues that are more resistant to DPP-IV cleavage 45 , and increasing its hydrodynamic radius ( R h) above the glomerular filtration cutoff by conjugating it to proteins such as transferrin 46 , albumin 47 , and elastin-like polypeptides 48

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Example 5: Isoelectric Point (Pi) Precipitation of Semapeptide Semapeptide present in cleavage sample was subjected to isoelectric point (pl) precipitation

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