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Cree is a physician scientist, pediatric endocrinologist, and associate professor at the University of Colorado Anschutz and Childrens Hospital Colorado

As viscosity increases, so does the force required to push the fluid through the needle, which can result in long injection times, incomplete injections, or delivery failures

Noabrupt discontinuation can trigger rebound appetite and metabolic disruption

The primary reason is to make the drug last longer and, therefore, save money

Key takeaways Most people start with a low dose of GLP-1s for weight loss

These include very long term effects beyond ten years, outcomes in younger populations who may use GLP-1s for decades, effects on bone health in older adults, and rare side effects that may only appear with widespread use over time