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Colchicine also has a major role when patients begin therapy with allopurinol (see below) to prevent the increase in gout attacks that can happen when allopurinol is begun

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Moreover, GHS-R1a is often referred to as the ghrelin receptors because ghrelin seems to be its primary natural ligand

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Phase 2 data published in the New England Journal of Medicine (2023) reported mean body weight reductions of up to 24.2% at the highest dose cohort over 48 weeks, surpassing outcomes seen with dual or single-receptor agents in equivalent trials

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