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Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)

Redox Biol 12:854-863

B., Saltiel, M

Hormonal fluctuations GLP-1 medications alter insulin sensitivity and other hormonal pathways, which can indirectly affect the hair growth cycle

Compounded medications are not FDA-approved for safety, efficacy, or quality

Conclusion GLP-1RAs show significant promise as a potential disease-modifying therapy for neurodegenerative and inflammatory eye diseases, acting through both systemic metabolic improvements and direct ocular mechanisms, representing a paradigm shift beyond their metabolic indications