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Yes, NAC dosage for dogs is contraindicated in animals which have a known hypersensitivity reaction to the drug

Lai J, et al

This is particularly important for the treatment of brain metastases, as brain tissue is highly sensitive to radiation, and inappropriate treatment can lead to severe neurotoxic effects [82, 83]

This cascade leads to endothelial injury, glomerular hyperfiltration, and enhanced macromolecule permeability which causes inflammation and glomerulosclerosis