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For weight management, NICE has appraised several licensed medicines that are available through NHS pathways or regulated private clinics: Semaglutide (Wegovy) NICE Technology Appraisal TA875 recommends semaglutide as an option for managing overweight and obesity in adults with a BMI of 35 kg/m or more (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when used within a specialist weight management service

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doi:10.1111/bph.15677

Correct Dosing Slow, careful titration reduces side effects

The associated weight loss benefits attracted attention and between 2021 -2024 when weight-loss approvals were obtained, media coverage dramatically increased demand

Retatrutide remains investigational in 2026 and has no MHRA authorisation