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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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For those managing a diagnosed deficiency, ongoing treatments may be recommended on a consistent schedule

Some neurological symptoms may continue improving for up to 1218 months, though permanent damage can occur if deficiency was severe and prolonged

& Schneiter, R