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Because GLP-1s modify the brain cells that produce serotonin and dopamine, some people report mental health side effects, including anxiety, depression and suicidal thoughts

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Chen, T.-H., Chang, C.-J

The enzyme dipeptidyl peptidase-4 (DPP-4) rapidly degrades circulating GLP-1, which is why pharmaceutical versions are chemically modified to resist this breakdown and maintain therapeutic levels for extended periods

Despite being extensively studied, current pharmacological and surgical interventions remain mostly symptomatic, leaving limited efficacy in halting or reversing disease progression