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And like all transformations, it comes with fire
The transition from functional fibroblasts to fibroblast activation and expansion to senescent myofibroblasts involves several steps of metabolic alterations, highlighting glycolysis, FAO and glutaminolysis as key processes
Chia TY, Gan C-Y, Shafie MH, Yap PG, Mohd Rodhi A, Ahmad A, et al
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This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) ( In addition to the NF-B pathway, the mitogen-activated protein kinase (MAPK) signaling cascade is also an important regulator of inflammatory responses in CNS microglia
Common additions: Thymosin Alpha-1 (broader immune modulation), MOTS-C (mitochondrial/metabolic support), or LL-37 (additional antimicrobial)
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