Complement activation, cytotoxicity, and alterations in cell junction proteins (e.g., reduced connexin-43) may also exacerbate tissue injury(Wroska et al., 2024)
This suggests that OXPHOS acts as a moderator of hemocyte function under normal conditions
He reports he is tolerating the side effects he is experiencing with dulaglutide 3 mg weekly but is not comfortable increasing the dose just yet
That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss
Previous studies have acknowledged the antioxidant properties of metformin 31,32,33
for example, Prevotella histicola , has been shown to inhibit RA development