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Silence or correct mutations: e.g., SNCA and LRRK2 via RNA interference (RNAi) or CRISPR-Cas9 (Niethammer et al., 2017

Moreover, CICR requires continual activation of VDCCs by Ca 2+ within intracellular microdomains, but not by robust Ca 2+ influx from extracellular spaces [8,15,17,24]