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Experimental validation Dose response curves and determination of IC 50 values were assessed for the 12 candidate drugs using 3-fold dilution series (see Supplementary Methods (Supplementary File 1) for more details)

doi: 10.1371/journal.pone.0149783

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Another mechanism by which IF reduces intestinal permeability is by increasing the abundance of Bifidobacterium in the gut

Individuals with chronic thromboembolic pulmonary hypertension exhibit differential methylation of multiple probes in pulmonary artery smooth muscle cells (PASMCs), which may be associated with PASMC remodeling