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P.TuerkP.et al (2018)

Active smoking significantly impairs wound healing and increases the risk of complications particularly relevant for a procedure that relies on tissue contraction and collagen remodelling

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The journey of a mature miRNA begins in the nucleus, where it is transcribed, typically by RNA polymerase II, as part of a long primary transcript known as a pri-miRNA, which can be thousands of nucleotides in length [33, 34]