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The GLP-1-producing preproglucagon (PPG) neurons located in the nucleus tractus solitarius (NTS) and the intermediate reticular nucleus of the medulla oblongata are the major source of endogenous GLP-1 in the central nervous system, which project widely throughout the central nervous system especially the autonomic control areas (Muller et al., 2019)

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You will also achieve better results if you use PT-141 consistently

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This direct administration is particularly beneficial for individuals with malabsorption issues, such as those with pernicious anemia, Crohn's disease, or celiac disease

That does not make it an approved treatment, but it does make it easier to study as a defined research compound