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Furthermore, the epidermis is a formative barrier that functions in preventing diffusion of molecules to the underlying dermis [2, 3]

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NRF 2 transcriptionally induces the expression of several antioxidant defense proteins involved in iron and ROS metabolism, such as SOD1, GPX4, glutathione synthetase (GCL and GSS), HO-1, and FTH 1 (8688)

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