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Metabolic stability studies indicated valproates metabolism is not primarily eliminated through CYP450, suggesting that the in vivo interaction likely results from inhibition of -oxidation or glucuronidation

This reduces the risk of hypoglycaemia compared to some other diabetes medications, though this risk increases when combined with insulin or sulfonylureas

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The non-targeted or pLKO.1-shGPX4 lentiviral particles were transiently transduced into K1 cells